ProgEvo Evolution Explorer
Explore co-occurring gene pairs and directional evolutionary routes inferred by ProgEvo from cohort-level molecular data.
Evolutionary network
Routes are shown as wild type baseline, detected present mutations, and cohort-inferred potential future downstream events.
EvoRisk is the proportion of cohort patients with the selected mutational context who had at least one downstream evolutionary route inferred by ProgEvo. Select at least one mutation to compute it.
Downstream evolutionary frequencies
Frequencies are derived from training the ProgEvo machine-learning model on the MDS IWG cohort.
Route-specific survival
Kaplan-Meier curves compare route-present, parent-only, child-only, and neither-mutated groups.