Routine molecular data
Mutational profiles and clinical variables from large MDS cohorts.
Technology · MDS
ProgEvo and IPSS-M-Evo
ProgEvo reconstructs cohort-level evolutionary routes in myelodysplastic syndromes and extracts the variables that extend IPSS-M into IPSS-M-Evo.
MDS
Evolutionary routes
IPSS-M-Evo
LFS and OS
Evolutionary order
Directional routes are inferred from co-occurrence and temporal structure at cohort level.
Compact variables
Only robust evolution-derived features with independent outcome signal are retained.
IPSS-M-Evo
A transparent extension of IPSS-M for research risk stratification.
Framework logic
From static mutation lists to evolution-aware risk
Curated genomic and clinical data from multi-cohort MDS datasets.
Directional evolutionary relationships between gene events.
Associations with leukemia-free and overall survival.
Integration with continuous IPSS-M and age-adjusted modelling.
Evidence
Peer-reviewed clinical evidence
The IPSS-M-Evo study is published in NEJM Evidence (DOI: 10.1056/EVIDoa2500124) and reports an evolution-informed extension of IPSS-M for MDS, with endpoint analyses for LFS and OS.